Apart from the basics (e.g. how to use #hashtags), it proposes categories for tweets as 'substantive' (e.g. those that convey information and a useful link), conversational ('this is what I am doing right now') and 'middle ground' (a bit of both).
I like the fact that it goes beyond being a corporate policy and actively explores ways that staff can use Twitter, including growing their audience and using it alongside teaching and research activities. Part of the LSE 'Impact of Social Sciences Project', the guide provides links to further resources such as staff already using Twitter, by faculty, and research into the use of Twitter and social media in science and higher learning.